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Case Studies

Engineering Compliance for an ISO Class 5 Medical Device
Cleanroom

The Partner: SourceONE Building Maintenance

Client Profile

Specialized Medical Device Manufacturer

The Challenge

Outdated SOPs and inadequate Work Instructions for high-sensitivity manufacturing

Environment

ISO Class 5 (Class 100) Controlled Environment

THE PROBLEM:

Documentation Debt in a Zero-Tolerance Environment

In 2024, a medical device company reached a critical juncture. Operating an ISO Class 5 cleanroom, where particulate counts must be kept under 3,520 per cubic meter, requires more than just physical cleaning; it requires “The Rule of Law” in the form of documentation.

The high-stakes reality:

The client’s existing Standard Operating Procedures
(SOPs) were outdated and lacked the technical granularity needed for modern medical device manufacturing. Without precise “Work Instructions,” the client faced:

Human Error Risks

Inconsistent staff protocols leading to potential batch
contamination.

Regulatory Exposure

Vulnerability during ISO and FDA audits due to vague documentation.

Operational Friction

A disconnect between high-level policy and the actual technical steps required on the cleanroom floor.

The Diagnosis

Bridging the Gap Between Policy and Practice

SourceONE’s initial assessment was not merely a walkthrough, but a deep-dive audit of the client’s compliance infrastructure. We identified three specific failure points:

01

Vague SOPs

The written procedures provided a “what to do” but failed to
explain the “how” or “why” required for ISO 5 compliance.

02

Missing Work Instructions

There were no tactical, step-by-step guides for technicians to follow, leading to procedural drift.
03

Outdated Standards

The protocols had not been updated to reflect current ISO 14644-1:2015 best practices.

THE SOURCEONE SOLUTION

Strategic Technical Consulting

SourceONE leveraged decades of cleanroom experience to act as a technical extension of the client’s Quality Assurance team.

Phase 1

SOP Optimization

We meticulously reviewed and suggested technical revisions to the client’s written SOPs. We refined the language to ensure it met the stringent requirements of medical device manufacturing and regulatory bodies.

Phase 2

Work Instruction Development

SourceONE helped develop a brand-new set of Work Instructions. These are the "boots on the ground" guides that dictate exactly how a technician enters, cleans, and maintains the ISO 5 space to ensure repeatable, compliant results.

Phase 3

Implementation & Training Support

We didn’t just hand over a document; we helped implement the new instructions, ensuring that the staff understood the science behind the new protocols.

THE RESULT

From "Good Enough" to Audit-Ready

By transforming their documentation from a static file into a functional tool, the client achieved a new baseline of operational excellence

Total Regulatory Alignment

The facility’s documentation now mirrors the precision of its engineering, fully satisfying ISO Class 5 requirements.

Repeatable Compliance

With clear Work Instructions, the risk of human-led contamination has been drastically reduced.

Scalable Success

The new documentation provides a blueprint that the client can use as they scale production or undergo future expansions.